功能性消化不良患者近端胃容受性的研究

Proximal Gastric Accommodation in Patients with Functional Dyspepsia

背景:功能性消化不良(FD)患者的近端胃容受性日益受到重视。目的:研究FD患者的近端胃容受性。方法:22例FD患者和20名健康对照者以内脏刺激器/电子气压泵检测近端胃容受性,并进行早饱试验。结果:FD患者的近端胃容受性为278.2ml±95.3ml,显著低于健康对照者的394.7ml±83.5ml(P<0.05),45.5％的FD患者存在近端胃容受性障碍;FD患者的近端胃容受性障碍与早饱症状有关(OR:11.11;95％ CI:1.53～76.92;P=0.013);早饱试验的检测结果与近端胃容受性正常与否无关(P=1.0)。结论:近端胃容受性障碍可能是FD患者重要的病理生理异常,并可能与早饱症状的产生有关,尚不能用早饱试验来预测近端胃容受性障碍。

Background: More and more attention is paid to proximal gastric accommodation in patients with functional dyspepsia (FD). Aims: To investigate the proximal gastric accommodation in patients with FD. Methods: Synectics visceral stimulator/barostat was used to study the proximal gastric accommodation in 22 patients with FD and 20 healthy controls, and all underwent a satiety testing. Results: In patients with FD the proximal gastric accommodation was 278.2 ml±95.3 ml, which was significantly lower than that in healthy controls (394.7 ml±83.5 ml, P<0.05), and 45.5% of patients with FD had impaired proximal gastric accommodation. The impaired proximal gastric accommodation in patients with FD was significantly correlated with the symptom of early satiety (OR: 11.11; 95% CI: 1.53～76.92; P=0.013), but the result of satiety testing was not related to proximal gastric accommodation (P=1.0). Conclusions: Impaired proximal gastric accommodation may be an important pathophysiological factor in FD and may be related to the symptom of early satiety, but satiety testing is unlikely to be able to predict impaired proximal gastric accommodation.