细胞免疫指标与溃疡性结肠炎严重程度的关系

The Relationship between Cellular Immunology Indices and Severity of Ulcerative Colitis LIU

背景:CD_4、CD_8阳性T淋巴细胞和可溶性白细胞介素-2受体(SIL-2R)作为细胞免疫的主要指标被认为与溃疡性结肠炎(UC)的严重程度有关,但其相关关系各学者意见不一。目的:观察外周血CD_4、CD_8阳性T淋巴细胞和SIL-2R水平与UC严重程度的关系及其在疾病缓解后的变化情况,以评估上述指标在UC临床诊治中的价值。方法:测定24例活动期UC患者的外周血CD_4、CD_8阳性T淋巴细胞和SIL-2R水平,其中10例患者的SIL-2R水平作治疗前后比较。结果:活动期UC患者的SIL-2R水乎显著高于健康对照组(P<0.05),且与疾病严重程度有关;CD_4、CD_8阳性T淋巴细胞水平则与健康对照组无显著差异,与疾病严重程度亦无关。经类固醇激素治疗症状缓解后,患者的SIL-2R水平显著下降(P<0.05)。结论:外周血SIL-2R水平与UC的严重程度和缓解密切相关,CD_4、CD_8阳性T淋巴细胞水平则无参考价值。

Background: As the main indices of cellular immunity indices, CD_4, CD_8 positive T-lymphocytes and soluble interleukin-2 receptor (SIL-2R) are considered to be related to the severity of ulcerative colitis (UC), but the opinions are different from various authors. Aims: To observe the relationship between peripheral blood levels in CD_4, CD_8 positive T-lymphocytes and SIL-2R, and the severity of UC, as well as their variations after remission; and to evaluate the clinical significance of these indices in the diagnosis and treatment of UC. Methods: CD_4, CD_8 positive T-lymphocytes and SIL-2R levels in peripheral blood of 24 active UC patients were assayed. In 10 of them, SIL-2R levels were compared before and after the medication. Results: The level of SIL-2R increased significantly in active UC patients compared with that of the healthy controls (P<0.05), and was related to the severity of the disease. There was no significant difference in CD_4 and CD_8 positive T-lymphocytes levels between active UC patients and healthy controls; and CD_4 and CD_8 positive T-lymphocytes levels were not related to the severity of the disease. The level of SIL-2R decreased obviously as soon as the symptoms were relieved with the steroid treatment (P<0.05). Conclusions: Peripheral blood level of SIL-2R is related to the severity and remission of UC, while the levels of CD_4 and CD_8 positive T-lymphocytes are of no reference value.