新的豆类凝集素FRIL及其体外维持造血干/祖细胞特性的作用机制

The Mechanisms of A New Plant Lectin FRIL from Dolichos Lablab That Preserves Quiescent Hematopoietic Stem Cells in Suspension Culture

凝集素是一类蛋白质或糖蛋白。自然界中 ,很多植物可产生凝集素。植物凝集素在分子间的识别过程中起着重要作用。本文主要就新近发现的豆类凝集素FRIL的生物学特性及体外维持造血干

Lectins, proteins that bind sugar moieties of glycolipids and glycoproteins, occur in all organisms and are especially abundant in many plants. Plant lectins probably have multiple roles related to their ability to act as recognition molecules. Here we present a review on the biological characterization of a new plant lectin in red kidney bean named Flt3 receptor interacting lectin(FRIL), and focus on the mechanisms that FRIL can preserve quiescent hematopoietic stem cells in suspension culture.