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内皮祖细胞在心脑血管疾病治疗中的应用 被引量:3

The application of endothelial progenitor cells (EPC) in the cellular and gene therapy of cardiovascular disease
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摘要 骨髓、外周血和脐血来源的内皮祖细胞取材和动员方便 ,能在体外扩增并能定向分化成功能性内皮细胞 ,在修复心肌梗死患者的心脏 ,治疗临床肢体缺血、冠状动脉疾病、脑中风 ,改善糖尿病患者的血管形成能力 ,定向抑制肿瘤血管生成 ,以及作为基因治疗导向载体和靶细胞等方面 。
出处 《生理科学进展》 CAS CSCD 北大核心 2003年第2期165-168,共4页 Progress in Physiological Sciences
基金 国家重点基础研究发展规划项目 ( 973) ( 0 0 1CB5 0 990 6 ) 国家高技术"86 3"计划领域重大专项 ( 2 0 0 2AA2 0 5 0 5 1) 国家高技术"86 3"计划主题项目 ( 2 0 0 1AA2 16 15 1)资助课题
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  • 1Walter DH, Rittig K, Bahlmann FH, et al. Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation, 2002, 105 : 3017 - 3024.
  • 2Edelberg JM, Tang L, Hattori K, et al. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res, 2002, 90 ,E89 - 93.
  • 3Iwaguro H, Yamaguchi J, Kalka C, et al. Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation, 2002, 105 : 732 -738.
  • 4Hess DC, Hill WD, Martin-Studdard A, et al. Bone marrow as a source of endothelial cells and NeuN-expressing cells After stroke. Stroke, 2002, 33 : 1362 - 1368.
  • 5Zhang ZG, Zhang L, Jiang Q, et al. Bone marrow-derived endothelial progenitor cells participate in cerebral neovaseularization after focal cerebral ischemia in the adult mouse.Circ Res, 2002, 90 : 284 - 288.
  • 6Shi Q, Bhattacharya V, Hong-De Wu M, et al. Utilizing granulocyte colony-stimulating factor to enhance vascular graft endothelialization from circulating blood cells. Ann Vase Surg, 2002, 16 : 314 -320.
  • 7Murohara T. Therapeutic vasculogenesis using human cord blood-derived endothehal progenitors. Trends Cardiovasc Med, 2001, 11 : 303 -307.
  • 8Reyes M, Dudek A, Jahagirdar B, et al. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest, 2002, 109 : 337 -346.

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