3-氯-1,2-丙二醇在大鼠体内的毒代动力学

Toxicokinetics of 3-chloro-1,2-propandiol in rats

目的 为了全面了解 3 氯 1 ,2 丙二醇 ( 3 MCPD)的毒理作用性质。方法 采用毛细管气相色谱 质谱 (GC MS)联用法测定大鼠血液中 3 MCPD的含量。结果 一次性给大鼠ig 75和 3 0 0mg·kg-1的3 MCPD后 ,血药浓度 时间的动力学符合一级吸收一室模型 ,t1/ 2kα 分别是 ( 1 .61± 0 .1 6)和 ( 1 .0 3±0 .1 9)h ,t1/ 2kβ是 ( 3 .40± 1 .0 1 )和 ( 7.3 8± 2 .76)h,tp为 ( 3 .2 4±0 .2 6)和 ( 3 .3 3±0 .3 9)h ,cmax为 ( 3 1±9)和( 2 1 5± 3 2 )mg·L-1,Cl是 ( 0 .2 7± 0 .1 0 )和 ( 0 .1 0±0 .0 4)mg·kg-1·h-1,V为 ( 1 .3 1± 0 .5 0 )和 ( 1 .0 1±0 .0 5 )L·kg-1。结论 结果表明 3 MCPD经胃肠道吸收入血快 ,在动物体内分布广泛。

AIM To comprehensively study the toxicological properties of 3 chloro 1, 2 propandiol(3 MCPD). METHODS Gas chromatography mass spectrum(GC MS) was employed to detect the concentration of 3 MCPD in the blood after ig. RESULTS The characteristics of blood concentration time curves fit the first order kinetics and one compartment model after ig 3 MCPD 75 and 300 mg·kg -1 . t 1/2 kα , (1.61±0.16), (1.03±0.19)h; t 1/2 kβ , (3.40± 1.01), (7.38±2.76)h ; t peak , (3.24±0.26), (3.33±0.39)h ; c max , (31±9), (215± 32)mg·L -1 ; clearance, (0.27±0.10), (0.10±0.04)mg·kg -1 ·h -1 ; and apparent volume of distribution, (1.31±0.50), (1.01±0.05)L·kg -1 , respectively. CONCLUSION 3 MCPD can be absorbed quickly through the alimentary tract into blood.