骨细胞间隙连接与物理—生物信号传导研究进展

Gap junctions of bone cell and biophysical signals transductions

物理信号特别是力负载在骨转换中起重要作用 ,而骨组织中的细胞成分是对其周围环境的刺激作出反应的基本结构单位 ,它们在接受刺激后通过结构和功能的调整从而作出反应。然而力负载通过什么途径对细胞群体产生作用 ,骨细胞对力负载引起的顺式反应机理至今还令人困惑。本文综合近年来一些最新实验研究 ,阐述骨细胞间隙连接 (gap junc-tion)在组成骨细胞网络 ,并通过间隙连接的细胞内通讯 (GJIC)机制在力学传递中的重要作用 ,其中对间隙连接的结构、功能 ,力负载 (如应力、底物变形、流体流动、电磁场等 )引起的生物物理信号在 GJIC的传递 ,GJIC对成骨细胞分化的调节等方面作了综述 ,并提出 GJIC的进一步研究与组织工程关系的启示。

Biomedical signals,especially mechanical loading plays an important role in the regulation of bone turnover.However,what is the mechanism and the downstream responses of bone cells to load induced signals is unclear.This review suggests that the gap junctional intercellular communication(GJIC) contributes to mechanotransduction in bone and to the regulation of bone cell differentiation by biophysical signals.Moreover,an implication of an integrated cell network essential for propagation of signals was indicated while biomaterial osteoblasts co culture is studied.