核酶在肺癌基因治疗中的应用被引量：1

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摘要核酶是一类具有酶活性的RNA分子 ,可序列特异性地切割靶mRNA ,从而有效抑制目的基因表达 ,且可重复使用 ,催化效率高 ,在抑制肺癌的发生。

作者谷仲平王云杰

机构地区第四军医大学唐都医院胸腔外科

出处《国外医学（呼吸系统分册）》 2003年第3期141-143,共3页 Section of Respiratory System Foreign Medical Sciences

关键词肺癌基因治疗核酶抑癌基因血管内皮生长因子多药耐药性

参考文献24

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1陆长德,陈农安,祁国荣.核酶对靶RNA的体外切割反应的计算机分析[J].生物化学与生物物理学报,1996,28(3):279-285. 被引量：22
2谷仲平,王云杰,李谨革,陈农安.血管内皮生长因子_(165)核酶的合成及其体外活性[J].第四军医大学学报,2002,23(3):272-274. 被引量：2
3谷仲平.血管内皮生长因子与肺癌(文献综述)[J].国外医学（外科学分册）,2002,29(4):232-234. 被引量：3
4Zhong-PingGu,Yun-JieWang,YuWU,Jin-GeLi,Nong-AnChen.Synthesis of ribozyme against vascular endothelial growth factor_(165) and its biological activity in vitro[J].World Journal of Gastroenterology,2004,10(10):1495-1498. 被引量：1

1谷仲平,王耀程,周勇安,李谨革,张涛,陈农安.抗血管内皮生长因子多位点核酶的合成及其体外切割作用[J].第四军医大学学报,2005,26(2):170-173.

国外医学（呼吸系统分册）

2003年第3期

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