摘要
肿瘤的生长是血管新生依赖性的。血管新生是由血管新生刺激因子和抑制因子之间平衡来调节。血管新生抑制剂可通过提高肿瘤细胞凋亡率来抑制肿瘤生长 ,提示血管新生与凋亡相关 ,凋亡受凋亡相关基因调控。凋亡相关基因与血管新生可能相关。
出处
《国外医学（呼吸系统分册）》
2003年第3期160-162,共3页
Section of Respiratory System Foreign Medical Sciences
参考文献22
-
1Griffioen AW, Barendsz-Janson AF, Mayo KH. et al.Angiogenesis, a target for t urnor therapy. J Lab Clin Med, 1998132:363-368.
-
2Folkman J. Tumor angiogenesis, therapeutic implications. N Engl J Med,1971 ,285:1182-1186.
-
3Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic Switch during tumorigenesis. Cell, 1996 , 86 : 353-364.
-
4Thompson CB. Apotosis in the pathogenesis and treatment of disease. Science, 1995 ,267 : 1456-1462.
-
5Korsmeyer SJ. Bcl-2 initiates a new category of oncogenes,regulators of cell death. Blood, 1992 , 80 ,879-886.
-
6O'Reilly MS, Holmgren L, Shing Y, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell, 1994,79:315-328.
-
7Brooks PC, Montgomery AMP, Rosenfeld M, et al. Integrinανβ3 antagonsts promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell, 1994 ; 79 : 1157-1164.
-
8Lu CD, Tanigawa N, Spontaneous apoptosis is inversely related to intratumoral microvessel density in gastric Carcinoma. Cancer Res, 1997 , 57 : 221-224.
-
9Folkman J. Clinical applications of research on angiogenesis. N Engl J Med,1995 ;333 :1757-1763.
-
10Aotake T, I.u CD, Chiba Y, et al. Changes of angiogenesis and tumor cell apoptosis during colorectal carcinogenesis. Clin Cancer Res. 1999 ; 5 : 135-142.
同被引文献8
-
1KRISTOF A S,,YOU Z,HAN Y S,et al.Protein expression of urotensinⅡ,urotensin-related peptide and their receptor in the lungs of patients with lymphangioleiomyomatosis. Peptides . 2010
-
2DJORDJEVIC T,GORLACH A.Urotensin-Ⅱin the lung:A matter for vascular remodelling and pulmonary hypertension?. Thrombosis and Haemostasis . 2007
-
3Bern HA,Pearson D,Larson BA,et al.Neurohormones from fish tails: the caudal neurosecretory system. I. "Urophysiology" and the caudal neurosecretory system of fishes. Recent Progress in Hormone Research . 1985
-
4Coulouarn Y,Lihrmann I,Jegou S,et al.Cloning of cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. Proceedings of the National Academy of Sciences of the United States of America . 1998
-
5Ames RS,Sarau HM,Chambers JK,et al.Human urotensin-Ⅱ is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature . 1999
-
6Eddahibi S,Fabre V,Boni C,et al.Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells.Relationship with the mitogenic action of serotonin. Circulation Research . 1999
-
7Griffioen,AW,Tromp,SC,Hillen,HF.Angiogenesis modulates the tumour immune response. International Journal of Experimental Pathology . 1998
-
8Takahashi K,Totsune K,Murakami O.Expression of uro-tensinⅡand urotensinⅡreceotor mRNAs in varioushuman tumor cell lines and secretion of uromnsinⅡ-likei mmunoreactivity by SW-13 adrenocortical carcinoma cells. Peptides . 2001
-
1王艳,宋英,买玲.Survivin、Caspase-3和Bcl-2在肺癌中的表达及意义[J].中国癌症杂志,2009,19(1):25-28. 被引量：7
-
2李晓东,曾进,黄海鹏,梅伟.血管新生抑制剂TNP-470对鼠ACHN肾细胞癌增殖与凋亡的影响[J].临床泌尿外科杂志,2003,18(8):490-491.
-
3刘兰.血管内皮生长因子对肿瘤血管生成影响的研究进展[J].中国病理生理杂志,2010,26(A10):2013-2013. 被引量：1
-
4黄雄.Fas介导凋亡信号传导研究进展[J].国外医学（输血及血液学分册）,1997,20(4):219-222. 被引量：2
-
5张苏江.抗血管新生治疗在血液肿瘤中的应用[J].国外医学（输血及血液学分册）,2003,26(2):116-119. 被引量：4
-
6柯昌能,盛青,刘维藩.原发性肝癌血管新生化和抗血管生成研究进展[J].肝胆胰外科杂志,2003,15(4):277-279.
-
7张建忠,李建业,田龙,张军晖,邢念增.前列腺癌TSP-1的表达与血管新生的关系及意义[J].临床泌尿外科杂志,2009,24(10):743-746.
-
8高力,张曦.血管新生抑制剂沙利度胺在多发性骨髓瘤治疗中的作用和地位[J].临床内科杂志,2013,30(6):378-380. 被引量：8
-
9张东梅,卿晨.血管内皮生长因子家族及其受体与肿瘤血管新生[J].医学综述,2017,23(3):417-420. 被引量：45
-
10向梅.血管新生抑制剂治疗妇科恶性肿瘤[J].国外医学（妇产科学分册）,2003,30(4):270-271.
