曲美他嗪治疗充血性心力衰竭的疗效观察

The effect of trimetazidine on the treatment of congestive heart faiture

目的 :观察曲美他嗪 (trimetazidine ,TMZ)治疗充血性心力衰竭 (CHF)患者的临床疗效。方法 :选择慢性CHF患者 6 8例 ,随机分为两组 :对照组 (34例 )给予洋地黄类制剂、利尿剂、血管扩张剂、血管紧张素转换酶抑制剂 (ACEI)或 β受体阻滞剂等常规药物 ;TMZ组 (34例 )在常规药物治疗基础上加用TMZ(2 0mgtid× 6 0d)治疗。结果 :TMZ组心功能改善的临床显效率 (4 7.1% )和总有效率 (91.2 % )均较对照组 (2 6 .5 %和 6 4 .7% )显著提高 (P<0 .0 1) ,且无不良反应出现。治疗后与治疗前相比 ,TMZ组心率、血压、左室射血分数、左室舒张末期容积、左室收缩末期容积均有显著改善 (P <0 .0 1或P <0 .0 5 ) ,TMZ组与对照组比较差异有显著性意义 (P <0 .0 1或P <0 .0 5 )。结论

Objective:To observe the effect of trimetazidine (TMZ) on the treatment of congestive heart failure (CHF).Methods:Sixty-eight cases of chronic CHF randomly received routine treatment (digitalis, diuretics, vasodilator, ACEI or β-blocker) or TMZ(20 mg tid×60 d)with routine therapy.Results:The tremtment efficiency of TMZ group and control group were 91.2% and 64.7%(P< 0.01), No adverse reactions related to the drug were observed. The improvements of HR, BP,LVEF,EDV,ESV after treatment in TMZ group were significant (P< 0.01 or P< 0.05). The difference between TMZ group and control group was also significant (P< 0.01 or P< 0.05).Conclusion:TMZ with routine therapy may be a safe way to treat CHF.