活血止痛丹的药效学研究

Study for Pharmacodynamics of Huoxuezhitong

目的:探讨活血止痛丹对大鼠微循环障碍的改善作用及抗炎镇痛作用。方法:观察活血止痛丹对右旋糖酐-40所致大鼠肠系膜微循环障碍的改善作用,并采用小鼠耳肿胀法、扭体法进行了研究。结果:活血止痛丹有一定的促进毛细血管开放作用,对血流速度、血流流态有一定的改善作用,能明显抑制二甲苯引起小鼠耳肿胀,明显减少0.6％冰醋酸所致小鼠扭体次数。结论:活血止痛丹可改善右旋糖酐-40所致大鼠肠系膜微循环障碍,并具有明显的抗炎、镇痛作用。

Objective: To evaluate the trunk-turning effects of huoxuezhitong. Method: Methods of trunk-turning and ear-swelling on mice were used, and the improving effect on the mesenteric microcirculatory obstruction in rats was observed. Results: Capillary vessels were expanded and velocity of blood flow and flow state were improved by huoxuezhitong after administration. Huoxuezhitong could obviously repress the ear swell of mice due to xylene and remarkably reduce the times of torsion caused by acetic acid. Conclusion: Huoxuezhitong can ease the mesenteric microcirculatory obstruction in rats due to dextran 40 glucose injection and have obvious anti-inflammation and analgesia effects.