肿瘤标志物CEA、CA_(19-9)、CA_(50)联合检测在胆管癌诊治中的作用

ROLE OF COMBINED TESTING OF SERUM TOMOR MARKERS IN THE OIAGNOSIS AND TREATNENT OF CHOLANGIOCARCINOMEA

目的 寻找对胆管癌诊断、疗效判断和随访有价值的肿瘤标志物。方法 采用 RIA联合检测 34例经手术和病理证实胆管癌和 2 1例胆囊息肉患者血清中 CEA、CA1 9- 9、CA50 的水平 ,并对其中 1 5例根治性切除的胆管癌患者进行随访。结果 血清 CA1 9- 9的敏感性和特异性最好 ,分别为 80 .1 5 %和 92 % ;胆管癌根治性切除后 ,患者血清 CA1 9- 9、CA50 水平较术前明显降低。结论 肿瘤标志物联合检测对胆管癌术前诊断。

Objective To investigate the value of serum tumor markers in diagnose,evaluating treatment effect and following up of cholangiocarcinoma.Methods Serum CA 19 9 CA 50 and CEA were detected by radioimmunoassay (RIA) in 34 patients with cholangicarcinoma which were proved by operation and pathology and 21 patients with gallbladder polyps, and utilized these markers to follow up 15 patients with radical resectable cholangiocarcinoma. Results Among these tumor markers, CA 19 9 was the best diagnostic index, its sensitivity and specificity were 80.15% and 92%, respectively.After radical removing tumor,the levels of serum CA 19 9 and CA 50 were decreased significantly compared with preoperation. Conclusion Tumor markers is valuable to preoperative diagnosis of cholangiocarcinoma,evaluating treatment effects and following up.