2-氯-4-氟-5-胺基苯基硫代乙酸合成路线的选择

The Selection of the Synthetic Route to Produce 5-amino-2-chloro-4-fluoro Phenyl Thioacetate

以 4 氯 2 氟 酰替苯胺为原料 ,经硝化 ,还原 ,重氮化 ,与巯基乙酸作用 ,水解反应制得化合物 2 氯 4氟 5 胺基苯基硫代乙酸甲酯 ,以 4 氯 2 氟 5酰替苯胺为原料经酰化 ,还原 ,缩合制得化合物 2 氯 4 氟 5 甲氧羰基硫代乙酸甲酯。通过比较 2条工艺方法的优缺点确定了最佳工艺路线。

Use 4-chloro-2-fluoro-acetanilide (5-amino-2-chloro-4-fluoro) phenylthio -acetate as raw material, through nitration, reduction, diazotization, reacting with thioacetic acid, and by hydrolysis to produce 5-amino-2-chloro-4-fluoro phenyl thioacetate. Use 4-chloro-2-fluoro-5-acetanilide,as raw material through acylation reduction, condensation.to produce 2-chloro-4-fluoro-5-mathoxycarbonyl thioacetate methyl ester. Optimal technology route were determined through the comparison of the advantage and disadvantage of the two technology process.