自乳化释药系统的体外评价

In vitro Evaluation of Self-Emulsifying Drug Delivery System

目的 探讨自乳化释药系统的体外评价方法。方法 通过测定自乳化时间、乳化后乳剂粒径的大小及模型药物的体外溶出行为对自乳化释药系统进行体外评价。结果 优选出的自乳化处方 10min内已基本乳化完全 ,乳化后乳剂粒子大小大多数在 3μm左右 ,以吲哚美辛和尼莫地平为模型药物制备出自乳化释药系统 ,体外溶出结果表明 :与混悬液相比 ,两种药物的体外溶出显著提高。

Aim To investigate the method of evaluation of self-emulsifying drug delivery system.Methods In order to investigate the self-emulsifying ability,the time of self-emulsifying,particle size of emulsion and the dissolution of model drug were determened.Results The selected formulation selected can fully emulsify in 10min and the particle size is about 3μm.Using indomethasin and nimodipine as model drugs,compared with their suspension,the self-emulsifying drug delivery system improved drug dissolution significantly.Conclusion Self-emusifying drug delivery systerm can increase the dissolution of poor water soluable drug in vitro.