越鞠胶囊内容物的药理作用

Pharmacological Effect of the Inclusion of Yueju Capsules

目的考察越鞠胶囊内容物 (theInclusionofYuejuCapsule ,IYC)与临床药效有关的药理作用。方法口服给药 ,采用乙醇致小鼠胃粘膜损伤模型、冰醋酸致大鼠胃溃疡模型、醋酸致小鼠疼痛模型、二甲苯致小鼠耳肿胀模型等考察受试物的药理学作用。结果在所选剂量范围内 ,IYC对乙醇致小鼠胃粘膜损伤和冰醋酸致大鼠胃溃疡模型均有显著的保护作用 ,且有一定的量效关系 ;对醋酸致小鼠扭体反应和对二甲苯致小鼠耳肿胀均有明显抑制作用 ;同时有显著的利胆作用。结论IYC对大、小鼠实验性溃疡的发生有明显的拮抗作用 ,并有一定的消炎、镇痛。

Objective To observe and study the prevention and therapeutic effect of IYC on the peptic ulcer.Methods To investigate the pharmacological effect of IYC in rats and mice by oral administration, peptic ulcer and gastric mucosal damage model,ear swelling one,stomache one,and so on were adopted.Results IYC significantly inhibited the gastric mucosal damage induced by absolute alcohol and showed marked analgesic effect on the stomachache caused by glacial acetic acid in mice.It was also found to inhibit the peptic ulcer induced by glacial acetic acid in rats.In addition,a remarkable stimulative effect was observed on the bile secretion in rats.Conclusion IYC oral administration has a significant prevention and therapeutic effect on the peptic ulcer.In addition,it has a significant analgesic,antiphlogistic and cholagogic effect.