摘要
目的在简介磷脂的基础上 ,概括了磷脂类似物和磷脂聚合物的合成方法及其在医药领域中的应用。方法在参阅国内外相关文献的基础上 ,进行分析、整理和归纳。结果磷脂聚合物的合成方法已经发展的比较成熟 ,但是在医药方面的应用主要限于磷脂聚合物型脂质体、聚乙二醇(PEG)修饰型脂质体和磷脂修饰型聚合物。
Objective To generalize the synthetic methods of phospholipid analogues and polymers and to review their applications to drugs based on crude phospholipids.Methods A number of native and international literature involved was analysed,rearranged and summed up.Results Although the synthetic methods of phospholipid polymers have been developed well,their applications to drugs are still confined to liposomes composed of polymeric phospholipids,liposomes modified by PEG and polymers modified by phospholipids.Conclusion Amphiphilic and biocompatible phospholipid analogues and polymers have broad future in the research and development in the field of medicine.
出处
《沈阳药科大学学报》
CAS
CSCD
2003年第4期302-307,共6页
Journal of Shenyang Pharmaceutical University
关键词
磷脂聚合物
磷脂类似物
合成
应用
phospholipid polymers
phospholipid analogues
synthesis
application
