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抗病毒药拉米夫定及其类似物合成研究概况 被引量：3

Survey of the synthesis of the antiviral drug lamivudine and its analogs
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摘要 目的综述抗病毒药拉米夫定 ( 3TC)及其类似物 ( - ) FTC的化学合成、药理活性研究进展。方法依据国内外有代表性的文献 ,对拉米夫定及其类似物 ( - ) FTC的化学合成、药理活性进行整理和归纳。结果明确了拉米夫定的合成工艺路线、作用机制等方面的情况。结论近年在抗爱滋病手性化合物的研发方面取得了很大进展 。 Objective To summarize progresses of chemosynthesis and biological activity of lamivudine(3TC) and its analog (-) FTC.Method By national and international representative literatures suming up and arranging chemosynthsis and biological activity of lamivudine(3TC) and its analog (-) FTC.Result Pinpointing the synthetic route of lamivudine (3TC) and its mechanism of action.Conclusion In recent years,there have been many progresses in researching and developing chiral compounds against virus.lamivudine(3TC) may be synthesized directionally via the synthetic route C.
作者 马红梅 鲍副刚
机构地区 华东理工大学化学与制药学院 东北制药总厂
出处 《沈阳药科大学学报》 CAS CSCD 2003年第4期308-312,共5页 Journal of Shenyang Pharmaceutical University
关键词 抗病毒药 拉米夫定 化学合成 (-)-FTC antivirus agent lamivudine chemical synthesis (-) FTC
分类号 R914 [医药卫生—药物化学]
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参考文献17

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共引文献79

同被引文献45

  • 1蓝晓红,王莉,李艳丽.近年来贺普丁应用的评述与研究[J].中国新医药,2003,2(6):48-50. 被引量：3
  • 2陈越磊,岑均达.拉米夫定合成路线图解[J].中国医药工业杂志,2005,36(1):60-62. 被引量：3
  • 3兰馨.乙肝用药头号大亨——贺普丁(拉米夫定)[J].中国处方药,2002,1(1):72-74. 被引量：1
  • 4张兆颖.拉米夫定临床研究进展[J].抗感染药学,2005,2(1):4-6. 被引量：13
  • 5谌宁生.中药联合拉米夫定治疗慢性乙型肝炎的临床研究进展[J].中西医结合肝病杂志,2006,16(6):379-381. 被引量：6
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  • 9JEONG L S, SCHINAZI R F, BEACH J W, et al. Asymmetric synthesis and biological evaluation of β-L- (2R, 5 S)-and α-L- ( 2R, 5R)- 1,3-oxathiolane-pprimidine and-purine nucleosides as potential anti-HIV agents[J]. Journal of Medicinal Chemistry, 1993,36 (2) : 181-195.
  • 10TYRRELL D L J,MITCHELL M C,DEMON R A,et al. Phase Ⅱ trail of lamivudine for chronic hepatitis B [J].Hepatology, 1993,18 (4) : 112A.

引证文献3

二级引证文献5

沈阳药科大学学报
2003年 第4期

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