2型糖尿病并发冠心病患者血尿酸水平的变化

Relationship between serum uric acid level and type 2 diabetes mellitus complicated by coronary artery disease

目的 :探讨血尿酸与2型糖尿病冠心病事件发生的关系。方法 :抽取2型糖尿病患者80名及糖尿病并发冠心病患者92名 ,调查病史、个人史和并发症情况 ,并观测心电图、体质指数及血尿酸等生化指标。结果 :并发冠心病组患者年龄、发病年龄、体重指数、舒张压、尿蛋白肌酐比率、血尿酸 (P<0.01)及血清甘油三酯 (P<0.05)均高于无并发症组。在以血尿酸为因变量的逐步回归分析中 ,血肌酐、腰臀比和体重指数先后进入方程 (P<0.05)。经年龄、性别、血脂调整后血尿酸水平高者发生冠心病事件的危险性提高 (OR=1.008,95 %可信区间为1.004～1.013) ,且在加入吸烟或高血压因素后差异更加显著。结论

Objective: To determine the relationship between serum uric acid(SUA) level and type 2 diabetes mellitus complicated by coronary artery disease(CAD).Methods:80 cases of type 2 diabetic patients(C group) and 92 diabetic patients complicated by CAD(DC group)were drew. In the morning,after an overnight fast,venous blood and urine was sampled for the measure of SUA and other biochemical assessments.Results:Age,body mass index,diastolic pressure,urine albumin creatinine ratio,SUA(P<0.01) and serum triglycerides(P<0.05) were all higher in DC group than those in C group. Logistic regression analysis with control of age,sex and serum lipid level were showed a significant relationship between SUA level and CAD(OR=1.008,95% CI=1.004～1.013), especially combined with smoking or hypertension. Conclusion:SUA level of type 2 diabetic patients is significantly related to the incidence of CAD.