胃液唾液酸直接测定对胃疾病的诊断意义

Effecf of direct assay of sialic acid in gastric juice on the diagnosis of gastropathy

唾液酸(Sialic acid)即N—乙酰神经氨酸(N—Acetyl—neuraminic acid)及其衍生物,是机体细胞膜糖蛋白和糖脂的主要成分。在细胞发生病理性改变,特别是恶性病变时,可使膜上浓度发生变化,并可溶于水溶液中,导致机体皿液或某些相关体液唾液酸浓度发生改变。文献中已有很多报告,组织细胞癌变血液中唾液酸含量可异常增加,而且与病情的严重程度呈正相关。如乳腺癌、宫颈癌、恶性淋巴瘤,肺癌等,其中呼吸系统恶性肿瘤可100％的高出健康人范围。我们利用空腹胃液直接从胃液中检测唾液酸含量,发现对胃疾病诊断及鉴别诊断具有一定意义,现报告如下:

Fasting gtastric juice was applied to determinate sialic acid, The result suggests that the mean content of sialic acid is 0. 075±0. 03mmol/L in normal group; 0. 193±0. 102mmol/L in ulcerous disease group; 0. 259±0. 112mmol/L in atrophicgastritis group and 0. 510±0. 320mmol/L in carcinoma of stomach group, and theabove three disease groups have significance as compared with the normal group (P<0. 01). Therefoe, the examination of sialic acid in gastric juice, togetherwith clinical gastroscope examination, has great significance in the diagnosis of gastropthy and the above method can be regarded as a auxiliary diagnosis of carcinoma of stomach.