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严重急性呼吸综合征相关冠状病毒的发现及其研究进程 被引量：2

Discovery of severe acute respiratory syndrome coronavirus
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摘要 严重急性呼吸综合征 (SARS)暴发流行 ,引发了一场全球性通力合作、激烈竞争的攻关研究。 2 0 0 3年 3月 ,中国香港及美国、加拿大和德国的科学家相继从 SARS患者标本中发现并分离到一种 SARS相关冠状病毒 (SARS- Co V) ,并得到世界卫生组织 (WHO)的确认。之后 ,2 0 0 3年 4、5月间 ,美国、德国、中国香港、加拿大、荷兰的学者分别将他们对 SARS病原体的研究成果发表于 Sciece、N EJM、L ancet、N ature等国际权威学术期刊上 ,先后报告了 SARS- Co V全基因组结构、基因组序列分析、SARS- Co V分子模型构建等 ,为进一步建立 SARS诊断、治疗及疫苗研究等奠定了基础。分析这一迅速取得大量成果的研究进程 ,认真反思、深刻总结 。 The epidemic of severe acute respiratory syndrome(SARS) leads both to close cooperation and fierce competition in related researches globally. In March 2003, scientists from Hong Kong (China), America, Canada and German discovered a new type of coronavirus in SARS patients(SARS CoV) successively. And it was acknowledged by the WHO. Later, from April to May 2003, researchers from America, German, Chinese Hong Kong, Canada and Dutch published their findings about SARS pathogen in journals like Science, New England Journal of Medicine, The Lancet and Nature, etc . The gene map, complete genome sequence and molecular model of SARS CoV were reported, which has laid a sound foundation for SARS diagnosis, treatment and the development of vaccine. We can learn a lot from the rapid reaction of the related institutes, and the experience gained will benefit us in the future.
作者 曹广文
机构地区 第二军医大学流行病学教研室
出处 《第二军医大学学报》 CAS CSCD 北大核心 2003年第6期632-635,共4页 Academic Journal of Second Military Medical University
基金 国家自然科学基金 ( 70 3 40 0 15 )
关键词 严重急性呼吸综合征 相关冠状病毒 发现 诊断 治疗 疫苗研究 severe acute respiratory syndrome pathogens coronavirus cooperative research
分类号 R563.1 [医药卫生—呼吸系统]
  • 相关文献

参考文献10

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同被引文献20

  • 1Wojtkowiak A,Siek A, Alejska M ,et al. RNAi and viral vectors as useful tools in the functional genomics of plants. Construction of BMV-based vectors for RNA delivery into plant cells[J]. Cell Mol Biol Lett,2002,7(2A):511-522.
  • 2Means JC, Muro I,Clem RJ. Silencing of the baculovirus Opiap3 gene by RNA interference reveals that it is required for prevention of apoptosis during orgyia pseudotsugata M nucleopolyhedrovirus infection of Ld652Y cells[J].J Virol,2003,77(8) :4481-4488.
  • 3Rubinson DA,Dillon CP,Kwiatkowski AV,et al. A lentivirus-based system to functionally silence genes in primary mammalian cells,stem cells and transgenic mice by RNA interference[J ]. Nat Genet, 2003,33 (3) : 401-406.
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  • 7Martinez MA, Gutierrez A, Armand-Ugon M, et al. Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication[J]. AIDS, 2002, 16(18) :2385-2390.
  • 8Park WS, Miyano-Kurosaki N, Hayafune M, et al. Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference [J]. Nucleic Acids Res,2002,30(22) :4830-4835.
  • 9Kapadia SB,Brideau-Andersen A, Chisari FV. Interference of hepatitis C virus RNA replication by short interfering RNAs[J]. Proc Natl Acad Sci,2003,100 (4) :2014-2018.
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引证文献2

二级引证文献5

第二军医大学学报
2003年 第6期

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