严重急性呼吸综合征相关抗体与激素应用的相关性及其临床意义

Relationship between SARS-related antibodies and steroid treatment and its clinical significance

目的 :探讨严重急性呼吸综合征 (SARS)患者体内 SARS相关抗体出现时间、抗体滴度与激素应用的相互关系及其可能的临床意义。 方法 :采集 2 2例 SARS患者 (临床诊断 )不同发病期及 3例 SARS密切接触者血清 ,采用酶联免疫吸附试验(EL ISA)检测其中的 SARS相关抗体 ,并对使用激素治疗的 17例 SARS患者进行追踪检测。 结果 :多数 SARS患者在发病后1～ 3d肺部未出现炎性病变征象前即可检测到 SARS相关抗体 ;3例密切接触者 SARS相关抗体也为阳性。 17例患者使用激素后 SARS相关抗体滴度均有所下降 ,其中 11例患者激素减至小剂量或停用后 ,有 10例患者 SARS相关抗体滴度较前上升 ,1例继续下降。 结论 :SARS相关抗体滴度与激素应用具有相关性 ,该抗体与

Objective: To analyze the appearing time of severe acute respiratory syndrome (SARS) related antibodies and the relationship between antibodies titer and steroid administration. Methods: We selected 22 SARS patients (clinically diagnozed) and 3 cases had close contact with SARS patients. Their sera were detected by enzyme linked immunosorbent assay(ELISA), including 17 cases received steroid treatment. Results: Most of SARS patients produced SARS related antibodies 1 3 d after onset before infiltration on chest radiography; the antibodies were also positive in 3 cases who had close contact with SARS patients. The titer of SARS related antibodies all decreased after using steroid in 17 patients. When steroid dosage was lowered or ceased in 11 cases, antibody titer raised again in 10 patients and kept decreasing only in 1 patient. Conclusion: There is relationship between the titer of SARS related antibodies and steroids administration.The relationship between SARS related antibodies with state of patients and clinical treatment deserve further research.