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药物处置的体外模型——Caco2细胞系 被引量：2

A Model in vitro of Drug Disposition-Caco2 Cell Line
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摘要 口服药物的生物利用度被认为仅与胃肠道吸收和肝脏的首过代谢有关.然而随着对小肠生理功能认识的深化,已经了解小肠在药代动力学过程中不仅专司吸收,还在药物的代谢、转运和消除中发挥着重要作用.
作者 吴笑春 辛华雯 余爱荣 仲明远 李罄 刘幼英
机构地区 广州军区武汉总医院临床药理科
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2003年第3期230-232,共3页 The Chinese Journal of Clinical Pharmacology
关键词 药物处置 体外模型 Caco2细胞系 肠吸收 P—糖蛋白 药物相互作用 enteral absorption drug disposition P-glycoprotein Caco2 cell line
分类号 R975 [医药卫生—药品]
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参考文献20

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同被引文献17

  • 1熊程亿,施绪保,代宗顺,方达超.~3H-小檗碱在家兔及小鼠体内的药代动力学研究[J].中国药理学通报,1989,5(5). 被引量：27
  • 2朱任之.甘草次酸钠对兔实验性心肌梗塞的影响[J].兰州医学院学报,1996,22(1):1-2. 被引量：7
  • 3陈波华,邢洪君,张影,罗荣,吕亚滨,闫灿霞.浅述黄连等中药抑制幽门螺杆菌生长的试验研究[J].黑龙江医药,1996,9(2):115-116. 被引量：55
  • 4Artursson P, Karlsson J. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epilchelia cells [J]. Biochem. Biophys. Acta, 1991, 175: 880-885.
  • 5Xueli Wang, Rufeng Wang, Dongming Xing, et al.Kinetic difference of berberine between bippocampus and plasma in rat after intravenous administration of Coptidis Rhizoma extract [J].Life Sciences, 2005,77: 3058-3067.
  • 6Tsai P L, Tsai T H. Simultaneous determination of berberine in rat blood, liver and bile using microdialysis coupled to high-performance liquid chromatography[J]. J. Chromatogra. A, 2002, 961: 125-130.
  • 7Pan J F, Yu C, Zhu D Y, et al. Identification of three sulfate-conjugated metabolites of berberine chloride in healthy volunteers urine after oral administration[J]. Acta Pharmacol. Sin., 2002, 23 (1) : 77-82.
  • 8Maeng H J, Yoo H J, Kim I W, et al. P- glycoprotein-mediated transport of berberine across Caco-2 cell monolayers[J]. J. Pharm. Sci. , 2002, 91 (12) : 2614-2621.
  • 9Chen Y Y, Wang X L, Sun H, et al. Characterization of the transportation of berberine in Coptidis rhizoma extract through rat primary cultured cortical neurons[J].Biorned. Chromatogr., 2008, 22:28-33.
  • 10杨秀伟,杨晓达,王莹,马莲,张悦,杨晓改,王夔.中药化学成分肠吸收研究中Caco-2细胞模型和标准操作规程的建立[J].中西医结合学报,2007,5(6):634-641. 被引量：99

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二级引证文献16

中国临床药理学杂志
2003年 第3期

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