摘要
目的 :探讨转化生长因子 (TGF)β1 和血管内皮生长因子 (VEGF)与腋淋巴结阴性乳腺癌 (ANNBC)临床病理及预后的关系。方法 :应用免疫组化技术 (L DP法 ) ,对 5 6例随访资料完整的女性 ANNBC根治标本进行 TGFβ1 和 VEGF检测 ,分析其表达与 ANNBC的预后关系。结果 :TGFβ1 和 VEGF表达与 ANNBC的年龄、肿瘤大小、病理类型、组织学分级等一般临床病理因素无相关 (P >0 .0 5 ) ,而与肿瘤复发、转移密切相关 ,TGFβ1 和 VEGF阳性表达的肿瘤复发转移率明显高于阴性表达者 (P <0 .0 1 ) ;TGFβ1 和 VEGF表达呈正相关 (P <0 .0 5 ) ;Cox比例风险模型多因素分析表明 ,TGFβ1 和 VEGF是影响 ANNBC的预后因子 ,TGFβ1 和 VEGF表达的 ANNBC病人预后差。结论 :1测定 TGFβ1 和 VEGF的表达 ,对判断 ANNBC病人预后及指导治疗有较大的帮助 ;2 TGFβ1 和 VEGF阳性表达与 ANNBC血管生成密切相关 ,是 ANNBC复发。
Objective:To investigate the relationship between the expression of transforming growth factor(TGF)β 1 , vascular endothelial growth factor (VEGF) and prognosis of axillary node negative breast cancer (ANNBC) .Methods:The expression of TGFβ 1 and VEGF protein in 56 cases of ANNBC was studied by immunohistochemistry LDP method. Correlations between the expression of TGFβ 1,VEGF and several of clinicopathological factors were studied.Result:No significant correlation was observed between TGFβ 1 ?VEGF and clinicopathological factors such as age, tumor size, pathological types and histologic grades of ANNBC.The expression of TGFβ 1 and VEGF correlated significantly with tumor relapse and metastatis (P<0 01). In addition, there was a positive correlation between TGFβ 1 and VEGF (P< 0 05). The multivariate Cox regression model indicated that TGFβ 1 and VEGF were independent prognostic factors in patients with ANNBC.Conclusion: ① It is helpful for predicting the prognosis and giving the assistant treatment of patients with ANNBC to examine the expression of TGFβ 1 and VEGF;② TGFβ 1 and VEGF are highly related to angiogenesis of ANNBC,and the positive expression of TGFβ 1 and VEGF may promote relapse and metastasis of ANNBC.
出处
《广西医科大学学报》
CAS
2003年第2期164-166,共3页
Journal of Guangxi Medical University
基金
广西柳州市科学研究与技术开发项目 ( No:2 0 0 1自 0 2 0 8)