哌啶衍生物的合成及其灭钉螺效果的研究

Synthesis of Derivatives of Piperidine and Their Effects on Snail-killing

目的 设计哌啶衍生物乙酸 β 哌啶乙酯和十二酸 β 哌啶乙酯的合成路线并研究其灭钉螺效果。 方法 以哌啶环为母体通过酯化反应引入不同的酰基合成哌啶衍生物 ,采用完全浸泡法研究合成产物的灭钉螺效果。结果 在不同浓度下乙酸 β 哌啶乙酯和十二酸 β 哌啶乙酯的 2 4h灭螺率与氯硝柳胺相当 ,而前两者对螺体的刺激小 ,钉螺的 2 4h开厣率高于氯硝柳胺 (P <0 0 5 )。结论 乙酸 β 哌啶乙酯和十二酸 β 哌啶乙酯有一定的灭螺作用 ,而且有利于钉螺开厣。

Objective To design the synthetic procedures of the derivatives of piperidine, β-piperidinyl-acetate and β-piperidinyl-dodecate and study their effects of snail-killing. Methods Through esterification the derivatives of piperidine were synthesized. By using complete immersing method, the effects of snail-killing of the synthesized products were observed. Results At different concentrations, β-piperidinyl-acetate and β-piperidinyl-dodecate had the 24-h snail death rate equivalent to that of niclosamide, but the former two derivatives showed less stimulating effects on the snails and a higher 24-h opening rate of operculum than the latter (P<0.05). Conclusion β-piperidinyl-acetate and β-piperidinyl-dodecate showed the effects of snail-killing to some degrees and were beneficial to the operculum opening of snails.