特发性血小板减少性紫癜患者感染的危险因素及预防措施

A study on risk factors and preventive measures of infections in patients with idiopathic thrombocytopenic purpura

目的 探讨ITP患者感染的危险因素 ,提出预防感染的相关措施。方法 对 6 7例ITP住院患者进行回顾性调查 ,对患者感染部位、性别、年龄、合并糖尿病情况、住院天数、使用激素及丙种球蛋白情况进行评估及统计学处理。结果 感染以呼吸系统最多 ,其次为泌尿道感染 ;年龄大、合并糖尿病、住院天数长 (>4周 )、应用激素量大与感染发生呈正相关 ,并进行Logistic多元回归分析 (P值分别 >0 .0 5、<0 .0 5、<0 .0 5、<0 .0 5 ) ,OR值分别约 1.385、9.16 9、8.90 0、18.6 6 7。结论 应用激素量大、合并糖尿病、住院天数长 (>4周 )是ITP患者感染的主要危险因素 ,其中应用激素量大最为重要 ,合并糖尿病次之 ;必须控制易患因素 ,有效地预防感染。

Objective To investigate the risk factors of infections in patients with ITP and to find out preventive measures for lowering the infection rate of the patients. Methods 67 cases of ITP were studied,area of occurrence infection,sex,age (>45 years),with diabetes,hospital stay(>4 weeks),glucocorticoids(prednisone>40mg/d over 5 weeks),γ-Globulin were collected and evaluated at the same time.Results Respiratory tract infection was the highest, the second one was the urinary tract;the rate of infection was related positively to age,with diabetes,longer hospital stay,the higher glucocorticoids;four factors were analysed with the Logistic regression equation(P>0.05,<0.05,<0.05,<0.05).The OR values were 1.385,9.169,8.900,18.667 respectively. Conclusion It was found that the main risk factors of infections in ITP patients were the higher glucocorticoids,longer hospital stay (>4 weeks), with diabetes,the risk factors were mainly the higher glucocorticoids and the others were diabetes etc.So it must be paid attention to the suscepetible factors, in order to effectively prevent infection of patients with ITP.