血管性血友病因子在偏头痛及脑血管病中的变化

Change of the von Willebrand factor in the migraine and cerebrovascular disease

目的 探讨血管性血友病因子 (vonWillebrandfactor,vWF)对偏头痛、脑血管病的影响。方法 以偏头痛、脑梗死、脑出血患者分别作为病例组 ,正常体检者和无血管性疾病的患者作为对照组 ,给予vWF水平测定。结果 偏头痛、脑梗死、脑出血患者vWF水平均高于对照组 (P <0 .0 5 )。结论 这些疾病有共同的发病基础 ,可能与内皮细胞的功能状态有关 ,vWF可作为一个标志物 ,为选择治疗药物、判断疗效和预后提供依据。

Objective To investigate the change of the von Willebrand Factor(vWF)in the migraine and cerebrovascular diseases.Methods The determination of vWF was performed in the patients with migraine,cerebral infarction,intracerebral hemorrhage,the healthy persons and the patients without cerebrolvascular diseases.Results The levels of vWF in the patients with migraine,cerebral infarction and intracerebral hemorrhage were significantly higher than those in healthy persons and the patients without cerebrovacular diseases.Conclusion The observed diseases possibly have a common background of onset of illness and vWF can be used as a marker and can provide basis for selecting treatment drug,judging therapeutic effect and prognosis.