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RT-PCR检测胃癌组织中尿激酶型纤溶酶原激活剂mRNA水平表达

Expression of Urokinase-type Plasminogen Activator mRNA in Gastric Cancer Tissues
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摘要 目的 研究尿激酶型纤溶酶原激活剂 (uPA)与胃癌的关系及其在胃癌浸润转移中的作用。方法 用荧光定量RT -PCR方法 ,分别检测 4 5例胃癌及其癌旁组织中 (uPAmRNA)水平的表达 ,并结合患者的临床生物学特征进行分析。结果  4 5例胃癌组织中 ,38例为阳性表达 ,4 5例癌旁组织中 12例表达阳性。在伴有淋巴结转移的胃癌中 ,uPAmRNA阳性例数明显高于无淋巴结转移者 ,两组例数分别为 2 7和 11例。结论 尿激酶型纤溶酶原激活剂uPAmRNA水平在胃癌组织中明显升高 ,且与胃癌浸润、转移密切相关。 Objective To investigate the expression of urokinase-type plasminogen activator mRNA in gastric cancer tissues and the role in tumor cell invasion and metastasis. Methods uPA mRNA expression was measured in gastric cancer and cancer-adjacent tissue of 45 patients by RT-PCR and, combined with patients' clinical biological feature, was analyzed. Results 38 cases were positive in 45 gastric cancer tissue while 12 cases were positive in all cancer-adjacent tissue. 27 cases of lymphatic metastasis were positive compared with 11 cases of non-lymphatic metastasis. Conclusion Expression of uPA mRNA increases in gastric cancer and it may contribute significantly to gastric invasion and metastasis.
作者 张景辉 夏耘
出处 《湖北民族学院学报(医学版)》 2003年第2期9-11,共3页 Journal of Hubei Minzu University(Medical Edition)
关键词 胃癌 尿激酶型纤溶酶原激活剂 RT—PCR 检测 肿瘤浸润 肿瘤转移 urokinase-type plasminogen activator RT-PCR Gastric cancer
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参考文献6

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