大剂量吗叮啉治疗胃食管反流病的疗效观察

Clinicla Effect of Large Dose Moltilium Treating Gastroesophageal Resiux Disense

目的 比较常规剂量吗叮啉与加大剂量吗叮啉治疗胃食管反流病 (GERD)的效果。方法 常规剂量组给予吗叮啉 10mg ,3次 /d口服 ,加大剂量组给予吗叮啉 2 0mg ,3次 /d口服。两组均同时应用法莫替丁 2 0mg ,一日两次口服。治疗一月后监测食管 2 4hpH值 ,进行 pH分析。结果 加大剂量吗叮啉治疗组 2 4hpH监测有关指标与常规剂量组比较有显著性差异 (P <0 .0 1)。

Objective The effect of treating Gastroesophageal reflux disease(GERD) with motilium between conventional dosage and increased dosage is compared. Methods Motilium is administered by taken orally in a dose of 10mg three times daily for conventional dosage group, 20 mg three times daily for increased dosage group, all together with Famotidine 20 mg two times daily which is taken drally. After a month, the value of oesophagus 24 h pH is monitored and the pH is analysed. Results The monitored index shows a striking dissimilarity bewteen conventional dosage group and increased dosage group.(P<0.01). ConclusionThe curative effect of increased dosage goes beyond that of conventional dosage.