摘要
雌激素对缺血性脑损伤具有保护作用。其作用机制是多因素的,涉及脑血管扩张、局部脑血流量增加、葡萄糖转运蛋白-1的表达、抗氧化作用、抑制兴奋性氨基酸和降低钙离子超载及上调抑制凋亡相关基因的表达等。
出处
《国外医学（麻醉学与复苏分册）》
2003年第3期151-154,共4页
Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
参考文献21
-
1Green PS, Simpkins JW. Neuroprotective effects of estrogens: potential mechanisms of action. Int J Dev Neurosci, 2000, 18:347-358.
-
2Alkayed NJ,Murphy SJ, Trastman RJ, et al. Neuroprotective effects of famale gonadal steroids in reproductively senescent female rats.Stroke, 2000, 31 ( 1 ) : 161-168.
-
3Simpkins JW, Rajakumar G, Zhang YQ, et al.Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat.J Neurosurg, 1997, 87(5) :724-730.
-
4Sudo S, Wen TC, Desaki J, et al. Beta-estradiol protects hippocampal CA1 neurons against transient forebrain ischemia in gerbil. Neurosci Res, 1997, 29(4) :345-354.
-
5Toung JK, Tmystrnan RJ, Hum PD, et al.Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke, 1998, 29 ( 8 ) :1666-1670.
-
6Hawk T, Zhang YQ, Rajakumar G, et al. Testosterone inereases and estradiol decreases middle cerebral artery occlusion lesion size in male rats. Brain Res, 1998, 796:296-298.
-
7White RE, Darkow DJ,Lang JL, et al. Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism.Circ Res, 1995, 77:936-942.
-
8McNeill AM, Kim N, Duekles SP, et al. Omaaie esmzgen treamaent increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels. Stroke, 1999, 30 : 2186-2190.
-
9Alkayed NJ, Hantkuni I, Kimes AS, et al. Gender-linked brain injury in experimental stroke. Stroke, 1998, 29(1):159-166.
-
10Shi J, Zhang YQ, Simpkins JW. Effects of 17β-estradiol on glucose transporter 1 expression an endothelial cell survival following focal ischemia in the rats. Exp Brain Res, 1997, 117(2) :200-206.
同被引文献5
-
1谭芳,周晓明.缺血缺氧性脑损伤中一氧化氮合酶的作用[J].中国临床康复,2005,9(29):152-155. 被引量：3
-
2Prokai L, Prokai-Tatrai K, Perjesi P, et al. Quinol-bused cyclic antioxidant mechanism in estrogen neuroprotection [J]. Proc Natl Acad Sci U S A,2003,100 (20):11741- 11746.
-
3Nilsen J,Diaz Brinton R. Mechanism of estrogen-mediated neuroprotection:regulation of mitoehondrial calcium and bcl-2 expression [J]. Proc Natl Acad Sci U S A,2003, 100 (5) : 2842-2847.
-
4李晓莉,高钰琪.雌激素对缺氧保护作用的研究进展[J].中国药理学通报,2003,19(2):134-137. 被引量：4
-
5熊金国,金正勇,许春花,池永学.雌激素对缺氧缺血新生大鼠脑细胞的影响[J].中华儿科杂志,2004,42(5):390-390. 被引量：2
-
1李艳.17β-雌二醇对缺氧缺血大脑的保护作用及机制[J].国外医学（神经病学．神经外科学分册）,2002,29(2):115-118. 被引量：3
-
2邱顺龄.养血清脑颗粒治疗慢性脑供血不足的疗效观察[J].中国现代医生,2008,46(8):91-91. 被引量：4
-
3周运贤.静脉输注尼莫地平治疗缺血性脑血管病122例护理体会[J].邯郸医学高等专科学校学报,2004,17(4):327-327. 被引量：1
-
4陶代兰.静脉输注尼莫地平治疗缺血性脑血管病112例护理体会[J].邯郸医学高等专科学校学报,2002,15(3):322-323.
-
5杨建辉,黄延寿.星状神经节阻滞治疗偏头痛50例报告[J].卒中与神经疾病,1996,3(1):31-32.
-
6Pascual J.M.,D.C. De Vivo,郭俊.葡萄糖转运蛋白-1缺乏综合征:临床、遗传特点及治疗[J].世界核心医学期刊文摘（神经病学分册）,2005,0(5):16-17. 被引量：2
-
7李中秋,陆兵勋,吕田明.高血压脑出血患者血肿周围血-脑屏障葡萄糖转运蛋白1表达的研究[J].临床神经病学杂志,2006,19(6):406-407. 被引量：2
-
8杨利杰,范丹,秦丹.依达拉奉治疗急性脑梗死临床疗效观察[J].中国医药导刊,2008,10(6):883-883. 被引量：2
-
9谭适.尼莫地平治疗蛛网膜下腔出血后脑血管痉挛的研究进展[J].华夏医学,2016,29(4):154-156. 被引量：4
-
10王新军,刘灵慧.尼莫地平治疗自发性蛛网膜下腔出血后脑血管痉挛的临床进展[J].国际神经病学神经外科学杂志,2011,38(6):584-587. 被引量：11
