血清脂联素水平与肥胖度的关系

Relationship between serum adiponectin concentration and adiposity

目的 研究上海地区人群血清脂联素(adiponeetin)水平与年龄、性别、体脂及血清瘦素水平的关系。方法 用放射免疫分析法测定104例正常非肥胖和57例超重或肥胖个体[体重指数(BMI)≥25kg/m^2]的血清脂联素水平。结果 正常非肥胖者脂联素男性(10.15±6.33)mg/L,女性(13.82±6.09)mg/L;超重或肥胖者脂联素男性(5.78±3.55)mg/L,女性(8.13±4.32)mg/L。正常女性血清脂联素水平高于男性,肥胖及超重个体血清脂联素水平显著低于正常人。脂联素浓度与BMI、腰围和体脂％呈显著负相关,与血清瘦素呈负相关,但扣除体脂因素后两者并尤明显相关性。在本年龄段中,脂联素与年龄关系不大。结论 脂联素作为脂肪细胞分泌的一种激素蛋白,其浓度变化可能与肥胖及其相关疾病密切相关,表明脂联素的增加可能是有益的。

Objective To investigate the relationships between serum adiponectin concentration and age, gender, body fat, and serum leptin concentration in Shanghai. Methods The serum adiponectin concentration was measured in 104 normal subjects [body mass index (BMI) <25kg/m2 ] and 57 overweight or obese subjects (BMI≥25 kg/m2) by RIA. Results The serum adiponectin concentrations of normal subjects were (10.15±6.33) mg/L in male and ( 13.82±6.09) mg/L in female,and those of overweight or obese ones were (5.78±3.55 ) mg/L in male and (8.13±4.32 ) mg/L in female. In both men and women, the fasting adiponectin levels in overweight or obese subjects were lower than those of the normal ones, and serum adiponectin concentration was significantly negatively correlated with BMI, % body fat, waist circumference and leptin concentration. But adiponectin was not significantly correlated with leptin concentration after the adjustment of body fat. Adiponectin was also not significantly correlated with age. Conclusion Adiponectin, a hormone secreted by adipocytes, may be intimately related to obesity and insulin resistance. Therefore, any treatment which increases adiponectin seems to be heneficial.