11β-羟类固醇脱氢酶与2型糖尿病

11β Hydroxysterold dehydrogenases and type 2diabetes mellitus

11β-羟类固醇脱氢酶(11β-HSDs)催化氢化可的松(皮质酮)和可的松(脱氢皮质酮)的相互转化,对调节局部糖皮质激素的活性起着重要作用,而糖皮质激素可诱导胰岛素抵抗。肝、脂肪等组织内11β-HsD活性的改变与肥胖、2型糖尿病等疾病密切相关。

11β Hydroxysterold dehydrogenases (11β-HSDs )catalyse the interconversion of active glucocorticoids(cortisol,corticosterone )and their inert 11β-keto derivatives(cortisone,11-dehydrocorticosterone)They play an important role in regulating the local glucocorticoids activities.Glucoeorticoids can induce insulin resistance.The alteration of 11β-HSD activities in tissues such as liver ,adipose tissue, is closely relevant to some common disorders,including obesity and type 2diabetes mellitus.