慢性肝炎肝硬化患者血清肝纤维化指标的检测

Delection of serum of hepatic fibrosis in patients with hepatits and hepatocirrhosis

目的 探讨检测慢性肝炎肝硬化患血清的TGF β1,IL 1和HA ,LN ,IV C ,PⅢP对肝纤维化的关系。 方法 用ELISA法测定血清TGF β1和IL 1的水平 ,用RIA法检测血清HA ,LN ,IV C ,PⅢP的水平。 结果 血清TGP β 1和IL 1的变化趋势与HA ,LN ,IV C ,PⅢP呈正相关。随着肝组织纤维化程度的加重 ,血清TGF β1,IL 1和HA ,LN ,IV C ,PⅢP的水平逐渐升高。结论 联合检测血清TGF β 1,IL 1和HA ,LN ,IV C ,PⅢP水平可做来评价肝纤维化动态改变的一种方法。

Objective To the serum levels of TGF β 1, IL 1,HA,IV C,PⅢP and their correlations with hepatic fibrosis in patients with hepatitis.Methods TGF β 1,IL 1, HA,LN,IV C,PⅢP were detected by ELISA and RIA. Results The results showed that TGF β 1 and IL 1 levels were significantly highter in patients with chronic hepatitis and hepatocirrhosis compared with normal subjects.The serum levels of TGF β 1 and IL 1 in viral hepatitis were closely related to the levels of serum HA, LN,IV C and PⅢP. Conclusion These results suggested that the change of TGF β 1 and IL 1 may be related to the pathogenesis of hepatic fibrosis.It may play an important role in the process from chronic hepatitis to cirrhosis.