慢性乙型肝炎患者外周血红细胞胰岛素酶活性研究

A study of the insulin degrading enzyme activity of erythrocytes in patients with chronic hepatitis B

目的 探讨慢性乙型肝炎 (慢性乙肝 )患者外周血红细胞胰岛素酶活性 (EIDEA)的改变 ,以间接反映其肝脏胰岛素灭活功能的改变。方法 采用放射酶分析法检测了 98例慢性乙肝患者及 5 0例正常人的EIDEA ,同时检测肝功能及乙肝病毒学指标。结果 慢性乙肝组血清ALT水平显著高于正常组 ,且其中HBVDNA阳性组血清ALT水平亦高于HBVDNA阴性组 (均为P <0 0 0 1) ;慢性乙肝组与对照组及HBVDNA阳性组与对应HBVDNA阴性组的EIDEA差异均无显著意义 (P >0 2、P >0 5 )。结论 慢性乙肝 (活动期及静止期 )

Objective To investigate the change of the insulin degrading enzyme activity of erythrocytes (EIDEA) in patients with chronic hepatitis B,and to reveal the ability of the liver for degrading insulin.Methods The EIDEA,the liver function and the parameters of hepatitis B virus were measured in 98 chronic hepatitis B patients and 50 normal persons.Results The levels of the serum ALT in the chronic hepatitis B were higher than those in the normal persons.And among the hepatitis B patients,the levels of the serum ALT in the patients whose HBVDNA were positive were higher than those in the patients whose HBVDNA were negative ( P <0 001).There were no significant differences in the EIDEA between the chronic hepatitis B patients and the normal persons,and so were there between the HBVDNA positive patients and the HBVDNA negative patients( P >0 2, P >0 5).Conclusion The activity of the liver for degrading insulin doesnt decrease in the chronic hepatitis B patients.