摘要
A series of novel chiral C 2 symmetric bis(oxazoline) ligands have been synthesized. The copper and magnesium complexes, prepared in situ from copper(II) triflate or magnesium triflate with the new enantiopure oxazoline ligands, were evaluated as chiral catalysts in the enantioselective Diels Alder reaction of cyclopentadiene with N crotenoyl oxazolidin 2 one. Primary results showed that diastereoselectivity up to 94% and enantioselectivity up to 68% ee for endo products were observed respectively with these ligands.
A series of novel chiral C 2 symmetric bis(oxazoline) ligands have been synthesized. The copper and magnesium complexes, prepared in situ from copper(II) triflate or magnesium triflate with the new enantiopure oxazoline ligands, were evaluated as chiral catalysts in the enantioselective Diels Alder reaction of cyclopentadiene with N crotenoyl oxazolidin 2 one. Primary results showed that diastereoselectivity up to 94% and enantioselectivity up to 68% ee for endo products were observed respectively with these ligands.
基金
ProjectsupportedbyNationalNaturalScienceFoundationofChina (No .2 0 172 0 0 1)andtheScientificResearchFoundationfortheRe turnedOverseasChineseScholars
MinistryofEducation .
