壳聚糖、羧甲基壳聚糖的降脂及抗氧化作用

Studies on Reducing the Plasma Lipid and Antioxidation of and Carboxymethyl Chitosan in Rabbits

目的:研究壳聚糖(Chitosan)、羧甲基壳聚糖(Carboxymethyl chitosan,CMCS)对高脂血症的新西兰白兔的降血脂及体内抗氧化作用。方法:40只新西兰白兔随机分为5组:正常对照组(A)、高脂模型组(B)、1％壳聚糖组(C)、1.5％壳聚糖组(D)、1.5％羧甲基壳聚糖组(E),分别以各组的饲料连续喂养6周。结果:壳聚糖、羧甲基壳聚糖降低血清甘油三酯(TG)、总胆固醇(TC)和低密度脂蛋白胆固醇(LDLc),明显升高血清高密度脂蛋白胆固醇(HDLc)。结论:壳聚糖的降血脂活性比其衍生物羧甲基壳聚糖高。壳聚糖及羧甲基壳聚糖还具有抗脂质氧化的作用,表现为降低兔血清中的氧化型低密度脂蛋白(OX-LDL)及丙二醛(MDA)含量。

Objective The effect of reducing plasma lipid and in vivo antioxidation of chitosan and carboxymethyl chitosan(CMCS) on the hyperlipidemic New Zealand White Rabbits were studies. Methods 40 rabbits were divided into five groups and fed with different diets for 6 weeks: basal diet ( group A); hypercholesterolemic diet ( group B);1% ( w/w) chitosan (group C) , 1.5% (w/w)chitosan (group D)and 1.5% (w/w)CMCS (group E) supplemented in hypercholesterolemic diet. Results The results indicated that chitosan and CMCS lowered TC,TG, LDLc levels in serum, followed by significant increase in serum HDLc . Conclusion The activities of reducing lipid of chitosan were better than those of CMCS. Chitosan and CMCS also prevented lipid from being oxidized, it characterized by a reduction in OX-LDL and MDA content.