大剂量纳洛酮治疗小儿重型颅脑损伤的临床研究

Clinical study of large dosage naloxone in treatment of children's severe brain injury

目的 探讨大剂量纳洛酮对小儿重型颅脑损伤患者的治疗作用。方法 大剂量纳洛酮治疗小儿重型颅脑损伤患者53例与同等条件下但未用纳洛酮治疗的同类患者53例比较。结果 纳洛酮实验组恢复良好26例(49.1％),死亡6例(11.3％),觉醒天数为(11.73±6.56)(n=45);对照组分别为16例(30.2％)及14例(26.4％),觉醒天数为(17.7±8.35)(n=35);两组比较均有显著性差异(P<0.05);实验组血浆β-内啡肽均值较对照组下降明显(P<0.01)。结论 小儿重型颅脑损伤早期应用大剂量纳洛酮治疗可降低死亡率,提高恢复良好率,缩短昏迷时间,治疗过程中未见毒副作用。

Objective To study the therapeutic effect of large dosage naloxone(NLX) on children's severe brain injury. Methods 53 patients in children's severe brain injury were treated with large dosage NLX,as many patients treated no NLX were taken as control.Results The results showed that 26 cases(49.1%) recovered satisfactorily and 6 cases(11.3%) died in NLX group while to no NLX group, 16(30.2%)and 14 (26.4%) cases respectively.There were significant in two groups ( P < 0.05); The time of awakening and conscious recovery in NLX group were shorter than that in control( P < 0.05); Blood β-EP content in NLX group was significantly decreased compared with that of the control group( P < 0.01) .Conclusion The effects of patients in children's severe brain injury can be improved by administration large dosage NLX. Moreover,no side effects and long dated complication was found.