大鼠用于尿生成影响因素的实验研究

Rats in the experiment of uropoietic influence factors

目的 探讨超龄超重大鼠代替家兔进行尿生成影响因素实验的可行性。方法 按照应用家兔进行尿生成的实验方法，观察超龄超重大鼠在各种因素影响下尿量的变化。结果 快速静脉输入生理盐水、葡萄糖、速尿后尿量明显增加，输入去甲肾上腺素和刺激迷走神经时尿量明显减少或无尿。结论 各项因素对超龄超重大鼠尿量变化影响显著，超龄超重大鼠可以代替家兔进行尿生成影响因素的实验。

Objective To investigate the feasibility of overage and overweight rats as an alternative to rabbits in the experiment of uropoietic influence factors.Mehtods The method of rat experimentwas the same as the rabbit′s,and then change in urine volume of overage and overweight rats under the influence of various factors was observed.Results The urine volume obviously increased with rapid venous infusion of normal saline,glucose and furosemide while obviously decreased or no urine with infusion of noradrenal...