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Na^+/H^+交换系统与心脏疾病 被引量：1

Na+/H+ exchanger and heart diseases
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摘要 目的　综述Na+ /H+ 交换泵 (NHE)的转录及活性调节机制 ,为诊治心脏疾病提供新的手段。方法　根据近期国外文献报道 ,较全面介绍NHE在心脏疾病中所扮演的角色。结果与结论　NHE是存在于所有脊椎动物细胞中的重要跨膜蛋白 ,该蛋白质涉及细胞的多种功能 ,包括细胞内 pH值调节、细胞体积的控制以及离子转运等。目前已克隆了 6个NHE亚型的cD NA ,构成脊椎动物细胞离子转运泵的一个基因家族 ,这 6个亚型的表达水平及活性受多种因素的调节。心肌缺血、缺氧可激活NHE ,进而激活Na+ /Ca2 + 交换引起心肌细胞内钙超载导致心肌损伤 ,NHE抑制剂可预防缺血
作者 刘皋林 陶霞
机构地区 第二军医大学长征医院药学部
出处 《中国药学杂志》 CAS CSCD 北大核心 2003年第6期401-404,共4页 Chinese Pharmaceutical Journal
关键词 Na^+/H^+交换系统 心脏疾病 细胞内PH值 转录 活性 调节机制
分类号 R972 [医药卫生—药品]
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参考文献22

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同被引文献26

  • 1Burckhardt G, Di Sole F, Helmle-Kolb C .The Na^+/H^+ exchanger gene family [J]. J Nephrol, 2002, 15(Suppl 5) :S3.
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中国药学杂志
2003年 第6期

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