固载相转移催化剂催化合成1,4-二氢-2,6-二甲基-3,5-吡啶二甲酸二乙酯

Synthesis of Diethyl 1,4-dihydro -2,6-dimethyl-3,5-pyridinedicarboxylate with Polymer-supported Phase Transfer Catalyst

采用三相相转移催化剂(四丁基溴化铵-聚苯乙烯树脂),以乙酰乙酸乙酯和六次甲基四胺为原料,合成了1,4-二氢-2,6-二甲基-3,5-吡啶二甲酸二乙酯,探讨了反应条件对产物收率的影响,并对产品结构进行了红外光谱及元素分析表征.

A new process has been developed to synthesize diethyl 1,4dihydro2,6dimethyl 3,5pyridinedicarboxylate from acetoacetic ester and hexamethylenetetramine by catalysis of triphase transfer catalyst (PSTBAB), and the reaction conditions on the yield of the product were studied. The structure of the product was confirmed by elemental analysis and IR.