EGFR、TGF-β1、p21^(WAF1/CIP1)在胃癌中的表达及意义

The expression and importance of EGFR、TGF-β1、p21^(WAF1/CIPI)in gastric adenocarcinoma

目的:探讨表皮生长因子受体 (EGFR)、转化生长因子 -β1(TGF-β1)、p2 1WAF 1 /CIP1 与胃腺癌发生、发展、转移的关系。方法:采用免疫组织化学方法对 6 4例胃腺癌组织和 15例正常胃组织 EGFR、TGF-β1、p2 1WAF 1 /CIP1 蛋白的表达进行检测。 结果 :EGFR、TGF-β1、p2 1WAF1 /CIP1 在正常胃组织及胃腺癌组织中阳性表达差异均有统计学意义(P均 <0 .0 5 ) ,三者在伴有或不伴有淋巴结转移的胃腺癌组织中阳性表达差异均有统计学意义 (P均 <0 .0 5 )。结论 :EGFR、TGF- β1表达、p2 1WAF1 /CIP1缺失与胃癌的发生、淋巴结转移密切相关 ;EGFR、TGF- β1、p2 1W AF 1 /CIP1表达的检测对胃腺癌的早期诊断及判断预后有重要意义。

Objective: To study the role of EGFR\, TGF β1\, p21 WAF1/CIP1 in the gastric adenocarcinoma. Methods: The expression of EGFR, TGF β1, p21 WAF1/CIP1 gene were detected in 64 cases of gastric adenocarcinoma and 15 cases of normal mucosa by immunohistochemistric technique. Result: The positive expression rates of EGFR, TGF β1, p21 WAF1/CIP1 between normal mucosa and in gastric adenocarcinoma were significantly different respectively (P<0.05). The rates of positive stain of EGFR, TGF β1, p21 WAF1/CIP1 between gastric adenocarcinoma tissue with lymph node metastasis and those without lymph node metastasis also showed significant differences respectively (P<0.05) Conclusion: The detection of EGFR, TGF β1, p21 WAF1/CIP1 is highly valuable in early diagnosis and prognosis of gastric adenocarcinoma.