脐血IL-10和IgE水平与婴幼儿过敏性疾病的关系

The Relationship between the Levels of IL-10 and IgE in Newborn Cord Blood and the Development of Infant Allergic Diseases

目的 :采集新生儿脐血并测定白细胞介素 10 (IL 10 )和IgE水平 ,通过 9～ 15个月的随访 ,追踪观察婴幼儿过敏性疾病的发生情况 ,以探讨 2种介质的变化与婴幼儿过敏性疾病的关系。方法 :采用酶联免疫法(ELISA)测定脐血IL 10 ,IgE的值。制定详细观察表 ,家访或电话随访 32 9例小儿发病情况。结果 :过敏性疾病组与未患过敏性疾病组比较 ,前者脐血IL 10较后者明显降低 (P <0 0 1) ,而IgE较后者明显增高 (P <0 0 1) ;对过敏性疾病患儿脐血IL 10 ,IgE进行相关分析显示 ,脐血IL 10与IgE之间呈显著负相关 (r =- 0 6 94 ,P <0 0 0 1)。结论 :出生时脐血IL 10降低和IgE增高与婴幼儿过敏性疾病的发生关系密切。过敏性疾病患儿的IL 10及IgE之间存在明显的相关性。

Objective:To measure the levels of interleukin 10 (IL 10) and IgE in newborn cord blood and to evaluate the relationship between IL 10 and IgE levels in cord blood and the development of infant allergic diseases. Methods: The levels of IL 10 and IgE in cord blood of 329 newborns were measured with ELISA. The incidence of infant allergic diseases was investigated through follow up observation. Data were analyzed statistically. Results: Comparing with the test results of infants without allergic diseases, the level of cord blood IL 10 was much lower, while the level of cord blood IgE much higher in infants who suffered allergic diseases later, (P<0 01, P<0 01). A negative correlation was found between the IL 10 and IgE levels. Conclusions: The increase of cord blood IgE and the decrease of IL 10 are significantly related to the development of infant allergic diseases. There is a significant negative correlation between IL 10 and IgE in infants with allergic diseases.