抗焦虑治疗对降压药效果的影响

Effect of Antianxious Therapy on the Effectiveness of Hypertension Pill

目的 :观察高血压伴有焦虑的患者中 ,抗焦虑治疗对药物降压效果的影响。方法 :117例高血压患者根据焦虑自评量表 (SAS)分为无焦虑组 72例 ,伴有焦虑 4 5例中再随机分为焦虑组 2 3例和抗焦虑组 2 2例。 3组患者均给予依那普利 5mg ,每日 2次 ,抗焦虑组同时加服抗焦虑药物治疗。 4周后比较 3组降压效果。结果 :无焦虑组及抗焦虑组的收缩压 (SBP)、舒张压 (DBP)均有明显下降 ,而焦虑组下降较小 ,与前 2组比较差异有显著性 (P <0 .0 0 1)。降压有效率 ,无焦虑组与抗焦虑组差异无显著性 ,分别为 80 5 %与 81 8%。而焦虑组为 5 2 17% ,与前 2组比较 (P <0 .0 5 )。结论 :焦虑情绪明显影响着降压药物的治疗效果 ,消除焦虑可明显提高药物的降压作用。提示高血压伴有焦虑的患者给予抗焦虑治疗是必要的。

Objective: To observe the influence of antianxious therapy on the effectivenss of hypertension pill in patients with hypertension and anxiety. Methods: 117 patients with hypertension were divided into nonanxiety group (72 cases) and anxiety group (45 cases) in light of SAS, and anxiety group was randomly divided into antianxious therapy group (22 cases) and control group (23 cases). The patients in the three groups were all treated with Enalapril 5 mg twice a day. The patients in antianxious therapy group were treated with antianxious therapy at the same time. The antihypertensive effects in the three gropus were compared after 4 weeks of continuous treatment. Results:The systolic blood pressure and diastolic blood pressure of the patients in nonanxiety and antianxious therapy groups were significantly decreased, but decreased in control group less than other two groups ( P <0.001). Effective rate was 80.5 % for nonanxiety group and 81.8 % for antianxious therapy group, but 52.17 % for control group. Comparison was made on the effective rate between control group and nonanxiety and antianxious therapy groups ( P <0.05). Conclusion: Anxious mood significantly interfered with the effectiveness of hypertension pill. The effect of decreasing pressure can be siginificantly increased with antianxious therapy. Our results suggest that it is necessary that patients with hypertension and anxiety are treated with antianxious therapy.