静脉用丙种球蛋白在新生儿ABO溶血症中的应用

Intravenous Injection of Immuneglobulin Therapy for Newborns with ABO Hemolytic Disease

目的 :探讨静脉注射大剂量丙种球蛋白 (IVIG)在治疗新生儿ABO血型不合溶血病中的疗效。方法 :ABO溶血症患儿 90例分为IVIG组 18例与常规组 12例 ,观察IVIG组在使用大剂量IVIG后血清胆红素下降情况。结果 :治疗 2d后评定疗效 ,IVIG组显效 12例 ,有效 5例 ,有效率 88 9% ,对照组显效 5例 ,有效 4例 ,有效率 75 0 % ,2组比较差异有显著性 (P <0 .0 5 )。结论 :大剂量IVIG能有效和快速降低ABO溶血患儿血清胆红素浓度。

Objective: To evaluate the therapeutic effects of intravenous injection of large doses of immuneglobulin in newborns with ABO hemolytic disease. Methods:Newborns were randomly divided into control group ( n= 12) and immunoglobulin group ( n = 18). Serum bilirubin levels were determined after therapy. Results:The effect of the treatment was assessed after 2 days. In the immunoglobulin group, 12 cases obtained significant effectiveness and 5 effectiveness with the effective rate being 88.9 %, while in the control group 5 cases obtained significant effectiveness and 4 effectiveness with the effective rate being 75 % ( P <0.05). Conclusion:Large dose of immunoglobulin can effectively and rapidly reduce the serum bilirubin of newborns with ABO hemolytic disease.