HIV阳性伴发抑郁情绪临床研究

Clinical study on depressive emotion of patients with positive HIV

目的 调查HIV阳性病人中抑郁症状发生率及治疗效果。方法 120名HIV阳性病人应用汉密顿抑郁量表(HAMD)进行调查,并以DSM-Ⅳ抑郁症症状诊断标准予以诊断。检出的抑郁病人随机分为心理治疗组(23例)和阿米替林治疗组(23例),分别接受心理治疗和阿米替林治疗,为期8w。结果 120名HIV阳性病人中有46例符合抑郁症症状诊断标准,HAMD≥20分。心理治疗组和阿米替林治疗组治疗前后自身比较均有显著性差异(P<0.01);阿米替林组与心理治疗组间比较有显著性差异(P<0.01)。结论HIV阳性病人中抑郁情绪的发生率较高。心理治疗和阿米替林治疗对抑郁症状均有明显效果,阿米替林治疗效果优于心理治疗。

Objective To investigate the incidence of depressive emotion and therapeutic efficacy in patients with positive HIV. Methods One hundred and twenty patients with positive HIV were investigated with Hamilton Depression Scale (HAMD) and diagnosed with Depression Diagnostic Criteria in DSM -Ⅳ, the selected patients were randomly divided into psychotherapy group(n = 23) and amitriptyline group(n = 23) which received psychotherapy and amitrityline respectively for 8 weeks. Results Of the 120 patients, 46 met depression diagnostic criteria. Self- comparison of both groups before and after treatment showed significant differences ( P < 0.01) , so did the comparison between the 2 groups( P < 0.01) . Conclusion The incidence of depressive emotion in patients with positive HIV is higher. Both psychotherapy and amitriptyline have clear effects on the depressive symptoms and amitriptyline is better than psychotherapy.