2Krieg A M,Yi A K,Klinman D M.CpG motifs in bacterial DNA trigger direct B-cell activation[J].Nature,1995,(374):546-549.
3Klinman D M,Yi A K,Beaucage S L,et al.CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6,interleukin 12,and interferonr[J].Proc Natl Acad Sci USA,1996,(13):2 879-2 883.
4Klinman D M,Yamshchikov G,Ishigatsubo Y.Contribution of CpG motifs to the immunogenicity of DNA vaccines[J].J Immunol,1997,158(8):3 635-3 655.
5Sato Y,Roman M,Tighe H,et al.Immunostimulatory DNA se quences necessary for effective imtradermal gene immunizatio[J].Science,1996,(273):352-354.
6Tokunage T,Yamamoto H,Shimad A S,et al.Antitumor activity of deoxyribonucleic acid fraction from mycobacterium bovis BCG Isolation,physicochemical characterization,and antitumor activity[J].J Natl Cancer Inst,1984,(72):955-962.
7Chu R S,Targoni O S,Krieg A M,et al.CpG oligodeoxynucleotides as adjuvants that switch on T helper 1(Th1) immunity[J].J Exp Med,1997,186(10):1 623-1 631.
8沈关心 周汝麟.现代免疫学实验技术[M].武汉:湖北科学技术出版社,2002..
9Wang D Q,Kandimalla E R,Yu D,et al.Oral administration of second-generation immunomodulatory oligonucleotides induces mucosal Th1 immune responses and adjuvant activity[J].Vaccine,2005,23:2614-2622.
10Pichyangkul S,Yongvanitchit K,Kum-arb U,et al.Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a toll-like receptor 9-dependent pathway[J].Immunol,2004,172(8):4926-4933.
