抗氧化维生素对辐射性晶体混浊的影响

Influence of antioxidant vitamin intake on radiant lens opacities

目的 为探讨抗氧化维生素对辐射性晶体混浊的影响。方法 把在放射工作人员体格检查中发现的晶体混浊者,随机分为治疗组和对照组,治疗组每日口服维生素C和维生素E各100 mg,每年观察晶体混浊情况。结果 治疗5 a后,晶体混浊由1级发展为2级以上者:治疗组101只眼中5只眼(4.95％),对照组90只眼中43只眼(47.78％)。治疗组晶体混浊加重者发生率显著低于对照组(x^2=43.39,P<0.005)。结论 抗氧化维生素可延缓放射工作人员晶体混浊的发展,其机制可能是血浆中抗氧化维生素浓度的增加,使晶体中抗氧化谷胱甘肽的含量增加,减少了晶体蛋白氧化和混浊的机会。

[Objective] To study the influence of antioxidant vitamin intake on radiant lens opacities. [Methods] 207 patients with lens opacities found in the physical examination on the X-ray workers were divided into two groups: treatment group and control group. The treatment group was given vitamin C100 mg and vitamin E 100 mg every day. The condition of lens opacity of the two groups was examined every year. [ Results] After 5 years of treatment, only 5 eyes of the 101 eyes in the treatment group developed from lens opacities classification Ⅰ to Ⅱ (4.95% ) , but the rate in the control group was 47 .78% (43/90) . The aggravation rate in the treatment group was significantly lower than that of the control group(x2 = 43 .39, P < 0.005) . [Conclusion] The development of lens opacities of the medical X-ray staff may be delayed by the intake of antioxidant vitamin, the principle of which may be that the increase of the density of antioxidant vitamins in the plasma increase the level of antioxidant glutathione in the lens and decrease the chance of the oxidation of crystalline.