尼尔雌醇与米索前列醇对绝经后妇女取节育环的作用

Effect of nylestriol and misoprostol on the extraction of contraceptive device in postmenopausal women

目的 探讨尼尔雌醇与米索前列醇对绝经后妇女取节育环难易程度的影响。方法 将150例符合绝经后放置节育环的妇女,随机各分为3组,每组50例:尼尔雌醇组(A组)5 mg,口服后7 d取环;米索前列醇(B组)600 mg,口服2 h后取环;C组取环前不用任何药物。结果 ①A与B组的宫颈软化差异无显著性(x_2=0.10,P>0.05);A、B两组与C组的宫颈软化差异有非常显著性(A与C组:x_2=15.43,B与c组:x_2=17.53,P均<0.01)。②取环成功:顺利A组与B组差异无显著性(x_2=0.38,P>0.05)A、B两组与C组均有差异非常显著性(与A组x_2=46.31,与B组x_2=52.17,P均<0.01)。结论 尼尔雌醇与米索前列醇对绝经后妇女取节育环难易影响相当,且安全、成功率明显提高。

[Objective] To study the effect of nylestriol and misoprostol on the extraction of contraceptive device in postmenopausal women. [Methods] 150 relevant patients were randomly divided into 3 groups with 50 cases each. Group A were given nylestriol 5m Po and contraceptive devices were extracted after 7 days; Group B were given misopostol 600 mg Po and contraceptive devices were extracted after 2 hours; Group C were given no drugs before the extraction of contraceptive device. [Results]1# There are no significant differences in uterine neck malacia between group A and group B(x2 = 0.10, P >0.05); there are significant difference in uterine neck malacia between group A and group C (x2 = 15.43, P < 0.01), between group B and group C (x2 = 17.53, P < 0.01) .2# There are not significant differences in the difficulty of extraction of contraceptive device between group A and group B (x2 = 0.38, P > 0.05) , but the significant difference was found between group A and C (x2 = 46.31, P <0.01), between group B and C (x2 = 52.17, P <0.01). [Conclusion] The effects of nylestriol and misoprostol are equal on the extraction of contraceptive device in postmenopausal women. Both drugs are curative and safe.