原发性骨淋巴瘤3例报告及文献复习

PRIMARY LYMPHOMA OF BONE:REPORT OF THERE CASES

目的 :报告 3例原发性骨淋巴瘤病例并复习国内外相关文献。方法 :化疗和放疗治疗3例原发性骨淋巴瘤患者。结果 :3例患者均对化疗、放疗敏感 ,并得到完全缓解。结论 :原发性骨淋巴瘤以 B细胞型非霍奇金淋巴瘤多见 ,可侵犯到骨的任何部位 ,通常为局限的溶骨性破坏。 PL B细胞存在 t(3;2 2 ) (q2 7;q11)染色体易位以及 bcl- 2、bcl- 6和 p5 3分子高表达 ,在 PL B病理过程中可能发挥重要作用。

Objective:Three primary lymphoma of bone are described and a review of the pertinent literature is introduced.Methods:3 patients with primary bone lymphoma were treated,2 patients had surgery as their local treatment and treated with chemotherapy (standard CHOP) followed by local radiotherapy. One patient was treated with chemotherapy and local radiotherapy.Results:3 patients achieved complete remission with no evidence of local recurrence.Conclusion:The majority of primary lymphoma of bone have been more recently characterized as diffuse large B cell lymphomas of primary non Hodgkin′s lymphoma of bone(PNHLB). Local bone lesions occur any bone of body in many patients with PLB. There are t(3;22)(q27;q11) and high expression of bcl 2,bcl 6 and p53 moleculars which may play a role in the pathogenesis of PNHLB.