中药对脑栓塞患者抗血栓作用的研究

Effect of Administration of a Traditional Chinese Prescription on Anti-Thrombosis in Patients with Cerebral Embolism

目的 :研究中药对风心脑栓塞患者的抗血栓作用。方法 :测定 31例风心脑栓塞患者 (男 18,女13) ,平均年龄 5 6± 8岁 ,运用加减桃红四物汤 ,对治疗前后血中抗凝和纤溶方面指标进行测定。同时测定 30例正常人血指标 (男 19,女 11) ,平均年龄 5 4± 4岁 ,所有病人服药 14天。结果 :用药后纤溶酶原 (PLG)、纤溶酶原活化素灭活剂 (PAI)比用药前下降 (p <0 0 5 )。AT -Ⅲ :A ,AT -Ⅲ :Ag ,tPA及D二聚体 (D -dimer)比用药前增加 (p <0 0 5 )。结论 :桃红四物汤具有一定抗凝作用 ,促进微血栓的纤溶过程 。

Objective To study the effect of administration of a traditional chinese prescription on anti-thrombosis in patients with cerebral emborism from rheumatic heart disease. Methods A traditional chinese prescription taohong siwu tang was given to the patients ( m=18, f=13, mean age 56±8yr) for 14 days. Blood anti-coagulation and fibrinolysis parameters were measured before and after treatment in these patients as well as 30 controls ( m=19, f=11 mean age 54±4yr). Results After treatment, the blood values of plasminogen and tissue plasminogen activator inhibitor were significantly lower than those before treatment ( p <0 05), while values of AT-Ⅲ:A, AT-Ⅲ:Ag, tPa and D-dimer were significantly higher ( p <0 05). Conclusion This tradifional chinese prescreiption possessed definite anti-coagulation effect, could promote fibrinolysis for microthrombi and might be of therapeutic value in treatment of patients with cerebral embolism.