摘要
目的 :评价自体卵巢组织移植性激素监测的价值。方法 :对 2 5例内异症保守手术后出现复发性疼痛和盆腔包块 ,药物治疗无效的Ⅳ期内异症患者 ,施行根治术时将自体卵巢组织片移植于大网膜之中。术后 4月每月测定卵泡刺激素 (FSH)、黄体生成素 (LH)和雌激素 (E2 ) ,E2 水平上升后 ,测定基础体温 ,每周做阴道脱落细胞检查 ,计算成熟指数 (MI)。根据基础体温及阴道脱落细胞检查 ,判断排卵期和黄体期 ,分别测定上述激素指标 ,连续 3个月 ,并与同年龄组正常育龄妇女和手术绝经妇女各 30例作对照。结果 :2 5例患者中 ,12例术后 4个月血清E2 水平上升 ,8例术后 6个月E2 水平上升 ,5例术后 12个月E2 维持在低水平 ,FSH、LH水平升高被列为卵巢组织失活。卵巢组织移植成活率为 80 0 %。卵巢功能恢复后 ,排卵期和黄体期性激素可达到正常生育年龄妇女水平。结论 :性激素监测是卵巢组织移植成败的有效指标。
Objective To evaluate the significance of monitoring serum sex hormones levels after ovarian tissue auto-transplantation. Methods Twenty-five patients with stage Ⅳ recurrent endometrosis after one or two times of conservative surgeries underwent radical surgery. Their ovarian tisuue fragments were transplanted to greater omentum. Serum follicle-stimulation hormone (FSH), Luteinizing hormone (LH) and estradiol (E 2) levels were measured monthly since fourth month post-operatively. After E 2 was increased, basal body temperature was measured and vaginal hormone cytology was examined weekly for maturation index (MI) to assess the ovulatory phase and luteal phase in those with viable ovarian tissues. Serum levels of FSH?LH and E 2 in ovulatory phase and luteal phase were determined 20 women with viable ovarian tissues for three cycles as well as in 20 normal sexually matue women and 20 operative menopausa women. Results There were 12 cases who had increasing of E 2 at four months post operatively and 8 cases more at six months. The other 5 cases with low serum E 2 levels and high FSH and LH levels at 12 months were designated as failures. The survival rate of transplanted ovarian tissue was 80 0%. There were no significant differences of the serum FSH, LH and E 2 levels in ovulatory phase and luteal phase between women with viable grafted ovarian tissues and normal sexually mature women. Conclusion Monitoring of sex hormones is a good means to assess the viability of the transplanted ovarian tissue fragments.
出处
《放射免疫学杂志》
CAS
2003年第3期173-174,共2页
Journal of Radioimmanology
