摘要
为研究补肾解郁清心方 (主药 :熟地黄、淫羊藿、白芍药、钩藤、龙齿、牡蛎 )对更年期抑郁症大鼠下丘脑 垂体 卵巢 (HPO)轴的干预作用。采用雌性SD大鼠卵巢切除与长期慢性不可预见应激法相结合 ,建立更年期抑郁症的动物模型。观察该方对模型大鼠行为学评分、糖水消耗量、生殖激素 (E2 、FSH、LH)以及神经递质 ( 5 HT、GnRH)的影响相比较。结果 :模型鼠经中药 2 1d治疗后 ,其水平积分、垂直积分和糖水消耗量均显著改善 ;血清FSH、LH ,下丘脑 5 HT、GnRH含量的紊乱也有显著纠正 ,但对E2 未见明显作用。结论 :补肾解郁清心方能够有效地改善更年期抑郁症大鼠紊乱的HPO轴 ,同时还能平衡GnRH与 5 HT的含量。
In order to study the interference of “Kidney-Tonifying, Depression-Relieving and Heart-Cleaning Formula' (main ingredients: Radix Rehmannia Praeparata, Herba Epimedii, Radix Paeoniae Alba, Ramulus Uncariae cum Uncis, Dens Draconis, Concha Ostreae) on hypothalamus-pituitary-ovary axis (HPO), the animal models with menopause depression were established by cutting off the ovaries of SD female rats, in combination of long-term unpredictable irritability, to observe influence of this formula on assessment of behavior, sugar-water consumption, reproductive hormones (E 2, FSH, LH) and nervous transmitter (5-HT, GnRH) in the modeled rats. The results showed that 21 days after the treatment with Chinese herbal medicine, the horizontal integral and vertical integral and sugar-water consumption were remarkably improved, and disturbance in serum FSH, LH, hypothalamus 5-HT, GnRH contents was also remarkably corrected, but without obvious function on E 2. The conclusion is that this formula can effectively improve disturbed HPO axis in the rats with menopause depression, and can balance GnRH and 5-HT contents at the same time. This is one of the possible mechanisms of this formula in the treatment of female menopause depression.
出处
《上海中医药大学学报》
CAS
2003年第2期38-41,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市科委基金资助项目 ( 0 45 0 1)
